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KMID : 0371320070730010021
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Journal of the Korean Surgical Society
2007 Volume.73 No. 1 p.21 ~ p.26
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Prognostic Value of the Preoperative CEA,CA15-3 and TPS Serum Levels in Patients with Breast Cancer
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Lim Yang-Soo
Jung Jin-Hyang
Park Ho-Yong
Lee Young-Ha
Ko Chang-dae
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Abstract
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Purpose: Tumor markers are often used to monitor the response to therapy and to detect recurrences in patients with resected breast cancer. Here we evaluated the prognostic value of the preoperative serum concentrations of tumor
markers in patients with breast cancer.
Methods: The preoperative serum concentrations of tumor markers (CEA, CA15-3 and TPS) were measured in 670 patients who were treated via potentially curative surgical resection for breast cancer from 2001 to 2004. We investigated
the association of the serum concentrations of tumor markers with the disease-free survival and overall survival at the time of the primary diagnosis in relation to the established prognostic factors such as tumor size, lymph node status, hormonal receptor status, age and menopausal status.
Results: The established prognostic factors and the elevated preoperative serum tumor marker values were correlated with disease-free survival (CEA: P=0.014, CA15-3: P=0.002 and TPS: P＜0.001) and overall survival (CEA: P=0.045, CA15-3: P=0.002 and TPS: P＜0.001) on univariate analysis. On multivariate analysis, tumor size, lymph node status, hormone receptor status and TPS (P=0.03) were independent prognostic factors for recurrence and the lymph node
status, hormone receptor status and TPS serum level (P＜0.001) were independent prognostic factors for overall
survival.
Conclusion: The preoperative serum concentrations of tumor makers (CEA, CA15-3 and TPS) are strong independent prognostic factors for recurrence and survival in patients with breast cancer. The tests for the preoperativeserum concentrations of tumor markers have convenient and reproducible advantages while the others require tumor tissue. Patients with elevated preoperative serum tumor marker values need appropriate adjuvant therapy, careful monitoring and detection of recurrences during the follow-up period.
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KEYWORD
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Breast cancer, Tumor marker, Prognosis
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